Patents

  1. 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use Alan Ashworth Christopher Lord, Richard Elliott, Dan Niculescu-Duvaz, Roderick Porter, Raymond Boffey, Melanie Bayford, Stuart Firth-Clark, , Ashley Jarvis, , Trevor Perrior, Rebekah Key PCT/GB2013/050561, WO/2013/132253
  2. Benzoxazine derivatives as Glycine transport inhibitors Richard Blunt, Andrew Eatherton, Mark Healy, James Myatt, Roderick Porter PCT/EP2010/062459 WO 2011023753
  3. Benzoxazine derivatives for the treatment of GlyT-1 related disorders Richard Blunt, Andrew Eatherton, Mark Healy, James Myatt, Roderick Porter PCT/EP2010/062459 WO/2011/012622
  4. Pyrrolidinone derivatives useful for the treatement of psychotic and neurological disorders Roderick Alan Porter WO2010018214 A2
  5.  Spiroimidazole compounds suitable for the treatment of neurological disorders Roderick Alan Porter WO2010018213 A2
  6. Compounds which inhibit the glycine transporter and uses thereof in medicine Cooper David Gwyn, Porter Roderick Alan PCT/EP2008/061890 WO2009034062  (A1)
  7. Spiro-condensed imidazolone derivatives inhibiting the glycine transporter Richard Blunt, David Gwyn Cooper, Roderick Alan Porter, Paul Wyman WO2009034061
  8. Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders.    Ahmad Nadia Mamoona; Lai, Justine Yeun Quai; Andreotti, Daniele; Marshall, Howard Robert; Nash, David John; Porter, Roderick Alan.   PCT Int. Appl.  (2008), WO  2008092876 A1
  9. Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders.    Coulton, Steven; Porter, Roderick Alan.   PCT Int. Appl.  (2008),  WO  2008092872  A1
  10. Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders.    Ahmad, Nadia Mamoona; Jaxa-Chamiec, Albert Andrzej; Lai, Justine Yeun Quai; Porter, Roderick Alan.   PCT Int. Appl.  (2008), WO  2008092873 A1
  11. Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders.    Ahmad, Nadia Mamoona; Lai, Justine Yeun Quai; Marshall, Howard Robert; Nash, David John; Porter, Roderick Alan.   PCT Int. Appl.  (2008), WO  2008092877 A2
  12. Preparation of aminophenylalkyl benzamides as Glyt1 glycine transporter inhibitors for treatment of psychoses, dementia, or attention deficit disorder.  Coulton, Steven; Gilpin, Martin Leonard; Porter, Roderick Alan PCT Int. Appl. (2007), WO2007147839 A1
  13. Preparation of N-[[1-dimethylaminocyclopentyl](phenyl)methyl]-4-fluoro-2-methyl-6-methoxybenzamide as a GlyT1 glycine transporter inhibitor. Coulton, Steven; Gilpin, Martin Leonard; Porter, Roderick Alan.   PCT Int. Appl. (2007), WO2007147836  A1
  14. Preparation of radiolabeled aminocyclopentylbenzyl benzamides as ligands for the GlyT1 glycine transporter.  Gentile, Gabriella; Herdon, Hugh Jonathan; Passchier, Johannes; Porter, Roderick Alan.   PCT Int. Appl. (2007), WO2007147838 A1
  15. Preparation of aminophenylalkyl benzamides as glycine transporter inhibitors.  Coulton, Steven; Gilpin, Martin Leonard; Porter, Roderick Alan.   PCT Int. Appl. (2007), WO2007147834 A1
  16. Preparation of 1-(2-aryl-2-oxoethyl)-3-phenyl-1,4-diazaspiro[4.5]dec-3-en-2-one derivatives as glycine transporter inhibitors.    Branch, Clive Leslie; Marshall, Howard; Nash, David John; Porter, Roderick Alan.   PCT Int. Appl.  (2007.  WO2007116061
  17. Preparation of (heterocyclic) aminoalkyl benzamides as glycine transporter inhibitors.  Coulton, Steven; Gilpin, Martin; Porter, Roderick Alan.   PCT Int. Appl.  (2007), WO2007113309  A2
  18. Preparation of N-phenyl-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl acetamide derivatives as glycine transporter inhibitors.  Coulton, Steven; Marshall, Howard; Nash, David John; Porter, Roderick Alan.  PCT Int. Appl.  (2007),  WO2007104775  A1
  19. Preparation of N-phenyl-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl acetamide derivatives and their use as glycine transporter inhibitors.  Coulton, Steven; Marshall, Howard; Nash, David John; Porter, Roderick Alan PCT Int. Appl.  (2007),  WO2007104776
  20. Preparation of N-phenylmethyl heterocyclic amides having activity at the glycine transporter GlyT1.    Branch, Clive Leslie; Marshall, Howard; Mccritchie, Jackie; Porter, Roderick Alan; Spada, Simone.   PCT Int. Appl.  (2007),  WO2007080159
  21. Preparation of diazaspirodecenyl- diazaspiroundecenyl- and diazaspirononenyl acetamides as GlyT1 transporter inhibitors for the treatment of psychosis.      Dean, Anthony William; Porter, Roderick Alan.. PCT Int. Appl.  (2007), WO2007014762  A2
  22. Preparation of acylated piperazines as glycine transporter inhibitors.      Bradley, Daniel Marcus; Branch, Clive Leslie; Chan, Wai Ngor; Coulton, Steven; Dean, Anthony William; Doyle, Paul Martin; Evans, Brian; Gilpin, Martin Leonard; Gough, Sharon Lisa; Macritchie, Jacqueline Anne; Marshall, Howard Robert; Nash, David John; Porter, Roderick Alan; Ward, Simon Edward.    PCT Int. Appl.  (2006),     WO  2006094842  A1
  23. Preparation of N-benzoyl piperazines as glycine transporter inhibitors.      Bradley, Daniel Marcus; Branch, Clive Leslie; Brown, Bethany Joy; Chan, Wai Ngor; Coulton, Steven; Dean, Anthony William; Doyle, Paul Martin; Evans, Brian; Gilpin, Martin Leonard; Gough, Sharon Lisa; Macritchie, Jacqueline Anne; Marshall, Howard Robert; Nash, David John; Porter, Roderick Alan; Stasi, Luigi Piero.    PCT Int. Appl.  (2006), WO  2006094843  A1
  24. Preparation of N-( -substituted benzyl) amides as glycine transport inhibitors.      Bozzoli, Andrea; Branch, Clive Leslie; Macritchie, Jacqueline Anne; Marshall, Howard Robert; Porter, Roderick Alan; Spada, Simone.    PCT Int. Appl.  (2006),  WO  2006067437  A1
  25. Preparation of N-[2-(dimethylamino)-2-methyl-1-phenylpropyl] benzamides as glycine transport inhibitors.      Bradley, Daniel Marcus; Branch, Clive Leslie; Chan, Wai Ngor; Coulton, Steven; Gilpin, Martin Leonard; Harris, Andrew Jonathan; Lai, Justine Yeun Quai; Marshall, Howard Robert; Macritchie, Jacqueline Anne; Nash, David John; Porter, Roderick Alan; Spada, Simone; Thewlis, Kevin Michael; Ward, Simon Edward..    PCT Int. Appl.  (2006),    WO  2006067417  A1
  26. Preparation of benzamides as glycine transport inhibitors.      Bozzoli, Andrea; Bradley, Daniel Marcus; Coulton, Steven; Gilpin, Martin Leonard; Macritchie, Jacqueline Anne; Porter, Roderick Alan; Thewlis, Kevin Michael.    PCT Int. Appl.  (2006),    WO  2006067414  A2
  27. Preparation of N-(phenylmethyl) benzamides as glycine transport inhibitors.      Bradley, Daniel Marcus; Branch, Clive Leslie; Chan, Wai Ngor; Coulton, Steven; Gilpin, Martin Leonard; Harris, Andrew Jonathan; Jaxa-Chamiec, Albert Andrzej; Lai, Justine Yeun Quai; Marshall, Howard Robert; Macritchie, Jacqueline Anne; Nash, David John; Porter, Roderick Alan; Spada, Simone; Thewlis, Kevin Michael; Ward, Simon Edward..    PCT Int. Appl.  (2006),    WO  2006067423  A1
  28. Preparation of N-( -substituted benzyl) amides as glycine transport inhibitors.      Bozzoli, Andrea; Branch, Clive Leslie; Macritchie, Jacqueline Anne; Marshall, Howard Robert; Porter, Roderick Alan; Spada, Simone.    PCT Int. Appl.  (2006),     WO  2006067430  A1
  29. Quinolinecarboxamides having activity at NK3 receptor and their preparations, pharmaceutical compositions and use for treatment of disease mediated by modulation of NK3 receptors.      Bradley, Daniel Marcus; Porter, Roderick Alan; Smith, Paul William; Stead, Rachel Elizabeth Anne; Vong, Antonio Kuok Keong..    PCT Int. Appl.  (2006),   WO  2006050991  A1
  30. Preparation of N-morpholinylphenyl-N-(piperidinylmethyl)acetamide derivatives and related compounds as GlyT1 transporter inhibitors for the treatment of mental disorders.      Branch, Clive Leslie; Nash, David John; Marshall, Howard; Porter, Roderick Alan..    PCT Int. Appl.  (2005),  WO  2005103000  A1
  31. Preparation of N-morpholinylpyridinyl-N-(piperidinylmethyl)acetamide derivatives and related compounds as GlyT1 transporter inhibitors for the treatment of neurological disorders.      Nash, David John; Porter, Roderick Alan..    PCT Int. Appl.  (2005),    WO  2005103038  A1
  32. Preparation of (morpholinyl)phenyl azabicyclooctyl ureas as GlyT1 transporter inhibitors for treating neurological disorders.      Bozzoli, Andrea; Branch, Clive Leslie; Marshall, Howard; Nash, David John; Porter, Roderick Alan..    PCT Int. Appl.  (2005),    WO  2005058317  A1
  33. Preparation of (piperidinyl)(morpholinyl)phenyl ureas as GlyT1 transporter inhibitors for treating neurological disorders.      Bradley, Daniel Marcus; Branch, Clive Leslie; Marshall, Howard; Nash, David John; Porter, Roderick Alan..    PCT Int. Appl.  (2005),     61 pp.  WO  2005058885  A2
  34. Preparation of compounds having morpholinyl and piperidinyl groups for use as GlyT1 and GlyT2 inhibitors for use in treating neurological disorders.      Branch, Clive Leslie; Marshall, Howard; Nash, David John; Porter, Roderick Alan.    PCT Int. Appl.  (2005),     53 pp.  WO  2005058882  A1
  35. Preparation of piperidinylhydroxypropylsulfamides as GlyT1 glycine transporter inhibitors for treatment of neurological and neuropsychiatric disorders.      Coulton, Steven; Porter, Roderick Alan..    PCT Int. Appl.  (2004),    WO  2004112787  A1
  36. N-(3-Amino-2-hydroxypropyl)benzenesulfonamide derivatives as GlyT1 transporter inhibitors, their preparation, and their use in the treatment of neurological and neuropsychiatric disorders.      Branch, Clive Leslie; Nash, David John; Porter, Roderick Alan..    PCT Int. Appl.  (2004),  WO  2004113280  A1
  37. Branch, Clive Leslie; Pilleux, Jean-Pierre; Porter, Roderick Alan.  Preparation of tetrahydroquinolines and tetrahydroisoquinolines as orexin receptor antagonists.    PCT Int. Appl.  (2004),  WO  2004041816  A1
  38. Coulton, Steven; Porter, Roderick Alan.  Preparation of N-(arylsulfonyl) cyclic amines as orexin antagonists.    PCT Int. Appl.  (2004) WO  2004041807  A1
  39. Chan, Wai Ngor; Nash, David John; Porter, Roderick Alan; Stead, Rachel Elizabeth Anne.  Preparation of N-(arylacetyl) cyclic amine derivatives as orexin antagonists.    PCT Int. Appl.  (2004) WO  2004041791  A1
  40. Preparation of N-aroyl cyclic amines as orexin receptor antagonists.      Branch, Clive Leslie; Coulton, Steven; Johns, Amanda; Nash, David John; Porter, Roderick Alan; Stemp, Geoffrey.  (Glaxo Group Limited, UK).    PCT Int. Appl.  (2004),   WO  2004026866  A1    
  41. Coulton, Steven; Hadley, Michael Stewart; Herdon, Hugh Jonathan; Jin, Jian; Joiner, Graham J.; Porter, Roderick Alan; Rahman, Shahzad Sharooq.  Preparation of GlyT1 transporter inhibitors and their use in treatment of neurological and neuropsychiatric disorders.    PCT Int. Appl.  (2003), WO  2003055478  A1
  42. Branch, Clive Leslie; Coulton, Steven; Nash, David John; Porter, Roderick Alan.  Preparation of piperazine derivatives as orexin receptor antagonists.    PCT Int. Appl.  (2003),   WO  2003051873  A1
  43. Coulton, Steven; Johns, Amanda; Porter, Roderick Alan.  Preparation of ethylene diamine derivatives as orexin receptor antagonists.    PCT Int. Appl.  (2003),  WO  2003051872  A1
  44. Branch, Clive Leslie; Johns, Amanda; Johnson, Christopher Norbert; Novelli, Riccardo; Porter, Roderick Alan; Stead, Rachel Elizabeth Anne; Stemp, Geoffrey; Thewlis, Kevin.  N-aroyl cyclic amine derivatives and their use as orexin receptor antagonist.  PCT Int. Appl.  (2003), WO  2003051871 A1
  45. Chan, Wai Ngor; Johns, Amanda; Porter, Roderick Alan; Stead, Rachel Elizabeth Anne; Vimal, Mythily.  Benzamide derivatives as antagonists of orexin receptors.    PCT Int. Appl.  (2003),  WO  2003037847  A1
  46. Branch, Clive Leslie; Chan, Wai Ngor; Johns, Amanda; Johnson, Christopher Norbert; Nash, David John; Novelli, Riccardo; Pilleux, Jean-Pierre; Porter, Roderick Alan; Stead, Rachel Elizabeth Anne; Stemp, Geoffrey.  Preparation of aroylazoles and aroylazines as orexin receptor antagonists.    PCT Int. Appl.  (2003),   WO  2003002561  A1
  47. Chan, Wai Ngor; Johns, Amanda; Johnson, Christopher Norbert; Novelli, Riccardo; Porter, Roderick Alan.  Preparation of N-acyl-2-heterocyclyl substituted piperidines and analogs as orexin receptor antagonists.    PCT Int. Appl.  (2003),  WO  2003002559  A2
  48. Branch, Clive Leslie; Coulton, Steven; Johns, Amanda; Johnson, Christopher Norbert; Porter, Roderick Alan; Stemp, Geoffrey; Thewlis, Kevin.  Preparation of N-aroyl cyclic amines as orexin antagonists.    PCT Int. Appl.  (2002),  WO  2002090355  A1
  49. Gaillard, Pascale; Johnson, Christopher Norbert; Novelli, Riccardo; Porter, Roderick Alan; Stemp, Geoffrey; Thewlis, Kevin Michael.  Preparation of N-aroyl cyclic amines as orexin receptor antagonists.    PCT Int. Appl.  (2002),   WO  2002089800  A2
  50. Novelli, Riccardo; Porter, Roderick Alan.  Preparation of condensed tricyclic piperidines having anti-convulsant activity.    PCT Int. Appl.  (2000), WO  0008023  A1.
  51. Coulton, Steven; Porter, Roderick Alan.  Preparation of 1-phenyl 3-pyrrolo[2,1-a]isoquinolinyl ureas as anticonvulsants.    PCT Int. Appl.  (2000), WO  0008022  A1.
  52. Coulton, Steven; Novelli, Riccardo; Porter, Roderick Alan; Thompson, Mervyn; Ward, Robert William.  Preparation of pyrido[2,1-a]isoquinolines and pyrrolo[2,1-a]isoquinolines as anticonvulsants.    PCT Int. Appl.  (2000), WO  0008020  A2.
  53. Coulton, Steven; Harling, John David; Porter, Roderick Alan; Thompson, Mervyn.  Preparation of substituted isoquinolines as anticonvulsants.    PCT Int. Appl.  (2000), WO  0007993  A1.
  54. Coulton, Steven; Johns, Amanda; Porter, Roderick Alan.  Preparation of phenyl ureas and thioureas as human orexin receptor antagonists.    PCT Int. Appl.  (2000),  WO  0047580
  55. Coulton, Steven; Johns, Amanda; Porter, Roderick Alan.  Preparation of phenyl ureas and thioureas as orexin receptor antagonists.    PCT Int. Appl.  (2000),     45 pp. WO  0047577  A1
  56. Johns, Amanda; Porter, Roderick Alan.  Preparation of cinnamide derivatives as orexin-1 receptors antagonists.    PCT Int. Appl.  (2000), WO  0047576  A1.
  57. Chan, George; Johns, Amanda; Jurewicz, Anthony; Porter, Roderick Alan; Widdowson, Katherine.  Preparation of quinolinylureas and related compounds as HFGAN72 antagonists.    PCT Int. Appl.  (1999), WO  9909024  A1.
  58. Thompson, Mervyn; Porter, Roderick Alan.  Preparation of substituted isoquinolinyl ureas as anticonvulsants.    PCT Int. Appl.  (1999), WO  9914197  A1.
  59. Hickey, Deirdre Mary Bernadette; Ife, Robert John; Leach, Colin Andrew; Pinto, Ivan Leo; Porter, Roderick Alan; Smith, Stephen Allan.  Preparation of pyrimidinone derivatives as Lp-PLA2 inhibitors.    PCT Int. Appl.  (1999), WO  9924420  A1.
  60. Coulton, Steven; Porter, Roderick Alan; Thompson, Mervyn.  Preparation of isoquinoline derivatives as anticonvulsants.    PCT Int. Appl.  (1999), WO  9925709  A1.
  61. Bondinell, William E.; Chan, James; Porter, Roderick A..  Preparation of 3-(4-piperidinyl or 1,2,3,6-tetrahydro-4-pyridinyl)-1H-indol-5-ols for treating a CCR5-mediated diseases.    PCT Int. Appl.  (1999), WO  9917773  A1.
  62. Johns, Amanda; Porter, Roderick Alan.  Preparation of naphthyridinylureas and related compounds as orexin A receptor antagonists.    PCT Int. Appl.  (1999), WO  9958533  A1.
  63. Coulton, Steven; Porter, Roderick Alan; Thompson, Mervyn.  Preparation of isoquinoline derivatives as anticonvulsants.    PCT Int. Appl.  (1999), WO  9925709  A1.
  64. Thompson, Mervyn; Porter, Roderick Alan.  Preparation of substituted isoquinolinyl ureas as anticonvulsants.    PCT Int. Appl.  (1999), WO  9914197  A1.
  65. Kitteringham, John; Porter, Roderick A.; Shipton, Mark R.; Vimal, Mythily; Young, Rodney C.; Borrett, Gary T.  Preparation of 3-methyl- and -ethylaminocarbazole-6-carboxamide enantiomers as 5-HT1-like receptor agonists.    U.S.  (1997), US  5618948.
  66. Porter, Roderick Alan.  (Pyrimidinyl)piperazines and Their Use as Medicaments.    PCT Int. Appl.  (1994), WO  9414779  A1.
  67. Porter, Roderick Alan; Vimal, Mythily.  Preparation of 3-amino-1,2,3,4-tetrahydrocarbazole-6-carboxamides as 5-HT1-like receptor agonists.    PCT Int. Appl.  (1994), WO  9414773  A1.
  68. Borrett, Gary Thomas; Kitteringham, John; Porter, Roderick Alan; Shipton, Mark Ralph; Vimal, Mythily; Young, Rodney Christopher.  Enantiomers of carbazole derivatives as 5-HT1-like agonists.    PCT Int. Appl.  (1994), WO  9414772  A1.
  69. Porter, Roderick Alan; Coates, William John.  Preparation of tryptamine analogs as 5-HT1-like agonists or partial agonists.    PCT Int. Appl.  (1994), WO  9414771  A1.
  70. Porter, Roderick Alan; Ward, John Gerard.  Preparation of tryptamine analogs as 5-HT1-like agonists and partial agonists.    PCT Int. Appl.  (1994), WO  9414770  A1.
  71. Porter, Roderick Alan; Prain, Hunter Douglas; Murray, Kenneth John; Warrington, Brian Herbert.  Phenol derivatives as agonists of a cyclic AMP-dependent protein kinase.    PCT Int. Appl.  (1993), WO  9310107.
  72. Porter, Roderick Alan; Prain, Hunter Douglas; Murray, Kenneth John; Warrington, Brian Herbert.  Preparation of 5-tetrazolyl-3-pyridinol derivatives and their use as medicaments.    PCT Int. Appl.  (1993), WO  9310114.
  73. Murray, Kenneth John; Porter, Roderick Alan; Prain, Hunter Douglas; Warrington, Brian Herbert.  2-pyridinol derivatives and their use as medicaments.    PCT Int. Appl.  (1993), WO  9310093  A1.
  74. Porter, Roderick Alan; Prain, Hunter Douglas; Murray, Kenneth John; Warrington, Brian Herbert.  Pyridinol derivatives as medicaments.    PCT Int. Appl.  (1993), WO  9307137  A1.
  75. Murray, Kenneth John; Porter, Roderick Alan; Warrington, Brian Herbert; Lahouratate, Philippe.  Phenol and pyridinol derivatives as lusitropic agents.    PCT Int. Appl.  (1993), WO  9319754  A1.
  76. Porter, Roderick Alan; Murray, Kenneth John; Warrington, Brian Herbert; Prain, Hunter Douglas.  Preparation of 6-phenyl-3-(5-tetrazolyl)pyridin-2(H)-one derivatives as cyclic AMP-dependent protein kinase agonists.    PCT Int. Appl.  (1992), WO  9206085.
  77. Murray, Kenneth John; Porter, Roderick Alan; Prain, Hunter Douglas; Warrington, Brian Herbert.  Preparation of arylpyridinones as drugs.    PCT Int. Appl.  (1991),  WO  9117987.
  78. Manley, Paul W.; Porter, Roderick A.; Lai, Mun F.  Preparation of 1-(2-alkenyl)imidazoles as thromboxane synthetase inhibitors.    U.S.  (1989), US  4837333.
  79. Lai, Steve Mun Fook; Manley, Paul William; Porter, Roderick Alan.  Alpha-[(phenylmethoxy)methyl]pyridinealkanol derivatives, procedure for their preparation, pharmaceutical composition containing them, and their use.    Eur. Pat. Appl.  (1988), EP  264114.
  80. Lai, Steve Mun Fook; Manley, Paul William; Porter, Roderick Alan.  Preparation of -(phenylalkyl)pyridinealkanols as platelet inhibitors.    Eur. Pat. Appl.  (1988), EP  267439.
  81. Manley, Paul William; Porter, Roderick Alan.  Preparation and testing of imidazopyridines as platelet-activating factor (PAF) antagonists.    Eur. Pat. Appl.  (1988),  EP  260613.
  82. Manley, Paul William; Porter, Roderick Alan; Lai, Mun Fook.  Substituted alkenylimidazoles.    Eur. Pat. Appl.  (1985),   EP  150892  A2